Delayed neutrophil apoptosis in patients with multiple organ dysfunction syndrome
نویسندگان
چکیده
From the Academic Unit of Anaesthesia and Intensive Care, School of Medicine, University of Aberdeen AB25 2ZD, UK (Drs. Noha El Sakka, Helen F. Galley and Nigel R. Webster), Department of Clinical Pathology, Faculty of Medicine, University of Alexandria, Egypt (Drs. Ola Sharaki, Myriam Helmy, Salah Marzouk and Mona Sedrak), and Department of Anaesthesia, Faculty of Medicine, University of Alexandria, Egypt (Dr. Shafik Azmy).
منابع مشابه
Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis
INTRODUCTION Deregulated apoptosis and overshooting neutrophil functions contribute to immune and organ dysfunction in sepsis and multiple organ failure (MOF). In the present study, we determined the role of soluble Fas (sFas) in the regulation of posttraumatic neutrophil extrinsic apoptosis and the development of sepsis. METHODS Forty-seven major trauma patients, 18 with and 29 without sepsi...
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Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scor...
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